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        Testosterone Resistance

        Fighting for the Men’s Health Hormone



Malcolm Carruthers
Xlibris (182 pp.)
$39.92 hardcover, $23.28 paperback, $4.99 e-book
ISBN: 978-1-5144-6567-7; March 9, 2016



A British doctor fights the stigma against treating his male patients with testosterone therapy in this summary of the medical uses for male hormones.

In this highly readable book, Carruthers (The Testosterone Revolution, 2001), a physician and medical consultant, passionately argues that testosterone replacement therapy treats not only “loss of libido” and “erection problems,” but also “memory loss, depression, irritability, joint pains, and night sweats.” He describes testosterone deficiency as “male menopause” and says that, in his medical opinion, treatment for the disorder should be much more widely available to men, particularly in the United Kingdom and Australia. He’s such a dedicated proponent of hormone therapies that after he and his colleagues gave a training course in testosterone treatment in Moscow in 2004, a professor nicknamed him “the father of testosterone treatment in Russia.” Carruthers goes on to offer two theories as to why such treatments aren’t popular: “peer pressure” from medical journals and the fact that some medications are sold at a mark up “designed to give testosterone treatment a bad name,” both of which seem to suggest a conspiracy. Overall, he seems to write from a place of genuine concern for his patients, and he offers scientific evidence to debunk what he says are two of the main myths about the safety of testosterone treatments: that they may lead to prostate cancer and/or cardiovascular disease. He also offers his very straightforward take on the mentality of his fellow doctors, saying that they are in “disease denial” and that their “Bold is bad!” attitude has led to “serious failure of medical practice.” His voice is refreshing, and it makes what could have been a dry medical textbook into an enjoyable read for anyone interested in emerging medical practices. He helpfully includes chapters that outline the medical reasons why a man might experience testosterone resistance and therefore need the treatments he advocates. Carruthers concludes that the “mobilization of public opinion in favor of testosterone treatment” is a key element in making it a mainstream, accepted practice. It’s clear that the author wants men to be able to live their best lives, and this book is a convincing argument that the medical community should take another look at the effectiveness of hormone therapies to help men do just that.

A book that illuminates the positive sides to testosterone therapy in a way that’s understandable for laymen.


Kirkus Indie, Kirkus Media LLC, 6411 Burleson Rd., Austin, TX 78744

       Testosterone Resistance

       Fighting for the Men’s Health Hormone




Malcolm Carruthers
Xlibris (Mar 15, 2016)
Softcover $23.28 (182pp)


This scathing critique of medical establishment orthodoxy presents a radical new approach to men’s health.

Malcolm Carruthers is a doctor on a mission in his latest book, Testosterone Resistance: Fighting for the Men’s Health Hormone. Not only does he make his best scientific and practical case for testosterone replacement therapy in aging men, but he skillfully turns the tables on a medical establishment that would proscribe his healing message.

Ironically, Carruthers is a major contributor to the medical establishment he criticizes. A doctor with great clinical experience, he’s also founder of the Centre for Men’s Health, president of the Society for the Study of Androgen Deficiency, adjunct professor in the Alzheimer’s and Aging Department at Edith Cowan University, and author of several books and more than a hundred articles in medical journals. These credentials help establish Carruthers’s credibility as he navigates a controversial topic.

Central to the book’s argument is the premise that testosterone deficiency—sometimes referred to as male menopause—is a serious systemic medical condition that can be linked to other conditions in men, including heart disease and Alzheimer’s. Extensively researched, with references included at the end of each chapter, the book argues with assurance that the common practice of testing hormone levels in patients to assess the need for testosterone is fallacious and misguided. Drawing parallels to diabetes, Carruthers shows how low testosterone in itself isn’t the problem; rather, low testosterone activity is, and the body’s resistance to the hormone’s “multiple complex actions” is what produces symptoms. Thus follows the book’s emphatic refrain: treat symptoms, not levels, so that men don’t suffer unnecessarily.

Besides providing ample evidence of the health benefits of testosterone replacement therapy, the book delivers a scathing critique of medical establishment orthodoxy. It criticizes both regulators, who level conspiratorial charges of profit motives behind “big pharma” hormone drugs, and the drug companies themselves that wrongly advertise such drugs as combating “low T” instead of “low T activity.” This critical double-edged sword suggests evenhandedness and the author’s sincere commitment to do well by his patients. Occasionally, the prose slips into hyperbole, using terms like “therapeutic nihilism,” but it stays on point overall, exposing a deep-seated bias toward “eminence-based medicine rather than evidence-based medicine.”

Some chapters are rigorously technical. The chapter on internal resistance, for example, uses complicated medical terminology to explain how cell receptors resist testosterone. Plentiful graphs and diagrams, however, simplify the science for the layperson. A symptom-based questionnaire included as an appendix further illuminates the book’s patient-centered, symptom-based approach.

Testosterone Resistance is aimed at the medical community, but it is written clearly enough to be informative for patients and other nonprofessionals interested in the increasingly contentious matter of testosterone deficiency. With this book, Carruthers expands discussion and awareness of men’s health issues.


Disclosure: This article is not an endorsement, but a review. The author of this book provided free copies of the book and paid a small fee to have his/her book reviewed by a professional reviewer. Foreword Reviews and Clarion Review make no guarantee that the author will receive a positive review. Foreword Magazine, Inc. is disclosing this in accordance with the Federal Trade Commission’s 16 CFR, Part 255.


            Testosterone Resistance

                Fighting for the Men’s Health Hormone
TESTOSTERONE RESISTANCE: Fighting for the Men’s Health Hormone
Malcolm Carruthers, MD
Xlibris, 164 pages, (paperback) $59.89, 978-1-5144-4909-7
(Reviewed: April, 2016)


The medical community’s ongoing controversy regarding the misunderstood effects of testosterone on the health of older males is the subject of this detailed, well-explained book.

Malcolm Carruthers, a men’s health specialist and authority on testosterone deficiency, has a long list of published papers and medical roles in the field. Extensive research has led him to conclude that many men with serious medical conditions, including heart and circulatory disorders, obesity and diabetes, can benefit from testosterone replacement therapy (TRT). However, many medical professionals deny such treatments to men, based solely on blood tests that fail to show low testosterone. Carruthers has found that men whose testosterone levels measure as normal actually have testosterone resistance, comparable to insulin resistance in diabetics, and TRT can improve their health issues.

Over the years, testosterone therapy was suspected of leading to prostate cancer and heart disease. However, scientific evidence has since disproven those claims and Carruthers’ studies show TRT can safely and effectively improve men’s body strength, vitality and energy without harm.

The author targets both lay and professional readers with this book, and his information is wellorganized and clearly presented. Charts, figures and a host of references enhance the data. At times, the discussion can be highly academic, which the author recognizes can be toughgoing for lay readers. At the start of Chapter Three, which presents full medical evidence for testosterone resistance, the author says the chapter “can be skipped if the reader is willing to accept that there is plenty of scientific evidence. . .”

Despite the largely serious approach, Carruthers occasionally offers a snarky remark regarding TRT naysayers; for example, “They resemble the regenerating life of vampires, who have to be nailed to the ground with a crucifix of a definitive rebuttal in a leading journal article.”

Overall, this is an informative, well-documented book that sheds fresh light on TRT. Despite the technical passages mentioned, it is likely to attract the interest of physicians and patients alike.

Also available in hardcover.